I've been using only EasyWeed, and recently purchased some Thermoflex because my supplier was out of the color I needed. I found Thermoflex harder to pull from the carrier sheet, but more stable (dots on the "i"s and such). You have to take more care when weeding the EasyWeed, but once you get used to it, it is very "easy"; it's just a different feel and technique. I prefer the EW for layering and larger fonts, but the TF for more detailed designs. I hated the TF for a long time until I upgraded my heat press... that changed my mind entirely. Remember that EW is made for the hobbyist - you can use it with an iron (with excellent results); I don't think it stands up as well to the fast weeding and pressing technique that many of us are used to, it just doesn't have much weight to it.