You can and I have. i only use it in a printer that I do NOT print portraits on. (color profile problems if you do) If you use it in a printer for printing, say negatives, it will work. You first have to filter it through a coffee filter a couple of times then mix it with pure black at a 50/50 ratio. Keep in mind i did this with an Epson printer though so I don't know if it will run through another. That's what i used to do. I use it a lot of other ways as well. I have tie dyed shirts, dyed wood and leather etc...Hope this helps.