I don't know how well the cleaning fluid works on waterbased, but the stuff is expensive enough that it isn't worth trying to remove an entire design from a shirt. Shirts are pretty cheap by comparison. The spot cleaning guns and chemistry are really just designed to remove small smudges, fingerprints, and so on. Plus, the stuff is nasty. I use it only when necessary and then as little as possible. If I have a printing error on a shirt, I print a new shirt.