So, with Wet on Wet on these, don't your screens build up and start 'bleeding'???
A little ink build up on the screens is ok, especially when printing detail heavy sim pro art that requires 7 or more inks. In addition to the actual wet on wet blending and mixing of colors - the core physics of simulated process - some print sequences can be engineered, at the color separation stage, to intentionally have a given screen "step" on certain areas to assist in achieving a desired result.
Successful wet on wet sim pro (as well as basic spot color artwork) relies heavily on proper screen tension. When nice and tight medium/high mesh counts are used, stopping to wipe the bottoms of the screens will be kept to an absolute minimum, even on high volume auto print runs. Keeping an eagle eye on your print for changes in detail crispyness will alert you as well. Like sben763 says, single floods and minimal strokes will also guarantee success. Of course the usual suspects also come into play such as proper off contact, level boards, squeegee durometer, ink viscosity, etc. so every design will have it's own reproduction/color sep parameters.
Ink mucking and bleeding can result from a low tension screen, excessive squeegee pressure, improper off-contact and again, overflooding. The inks gotta go somewhere. Smash and flash is no way to screen print!