Generally, it does fine. There are some quirks, the biggest of which is printing white onto red 50/50 shirts, as the red dye migrates into the white print, so you get a pinkish print on a red shirt.
Mostly, it's not a big deal at all, and some 50/50 shirts are pretty soft, so they are nice. I'm going to do 120 brown prints on white 50/50 gildan g800 wednesday and don't expect any problems, anything different than a 100% cotton Gildan.
I specialize in discharge printing, and that doesn't work on 50/50 like it does on 100% cotton, which sometimes is cool. Check out my blog or site for examples of that, if'n you want.
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