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I would stick to Illustrator first as i think it's an easier package to learn and easier to print low cost t shirts from, i.e. vinyl cut rather than screen printing as you need a fair bit more money for screen.
 

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Before you start setting up artwork in either application just think about how you're going to finally print your designs. I currently print using vinyl so i can only really use illustrator for that as you need cutter guides etc. if you're screen printing then i guess you could use either app.
 
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