Photoshop, change to cmyk mode, then select color range, save selection for each color, print. Google it, checkout ryoets early video tutorials, get seps studio, email me and I'll do it for you.
That's up to you and what kind of equipment you have. Some people can hold 65 lpi easily and some struggle with 45 lpi. It all depends on your emulsion, exposure unit, ect. Then it goes to whether or not your press will hold registration enough for smaller dots.Thanks alot for the offer, however through some trial and error I think I have figured it out.
One question I still have is what lpi and mesh would you recommend for this image?