There are a ton of possibilities - a few that come to mind quickly ... the dryer is too hot or not hot enough, the ink isn't mixed properly (needs a good stir or maybe a bad batch), the ink is too old, you're printing on waterproof nylon or some other strange material?
What temperature is your dryer? What material are you printing on? Is the ink mixed well and is it new? Have you tried printing a different color of ink with the same results?