With a 4 color manual, there is no possible way to do a 4cp. That job would be a minimum of 5 screens with the white. In my shop it would be 4 screens for the 4cp 2 for the whites and at least 2 spot colors. in simulated, i think it could be 6 to 8 colors also. it would be possible with 4 colors, white, yellow, some kind of red, and black for the detail in the bottle. If you have time, try different colors and seps. Good luck
on a dark ground you could possibly get away with process printing without using cyan (i believe all the colors/tones/shades in this design could be produced with just black,yellow and magenta on a white under base) you would need to print flash print flash the under base for a bright white, this would give a strong hand feel tho.
Simulated process would be good but i think you could achieve more color tones using process for this design.
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