Assume you mean differences with plastisol silkscreening?
Yes. Firstly, dtg uses a water based pigment ink. There is no or little hand.
Colors are not as vibrant as you could get with plastisol silkscreening (bracing myself for an onslaught of disagreement

) You don't get that pop of color out of a dtg like you would with silkscreening.
Also, the sheer number of colors or color shading would be greater with dtg.
The differences are not so great when you compare water based silkscreening to dtg. The giveaway usually is the number of colors a dtg printer can give you.