Hi, we use Volusion for our site. It has good tutorials and if you have some knowledge of web design, it is pretty easy to use. It has a lot of good features, like built in SEO, tons of ways to look at the data coming into and going out of your site, an active community forum area where members provide help, feedback, and assistance, live shipping, and a lot of templates to use, should you choose to use a template. The site can be really customized as well, of course. You can check out a high profile Volusion example here:
Official Ed Hardy Store by Christian Audigier - California Lifestyle Fashion Brand. or, kind of interesting, the official Barack Obama store uses Volusion, here:
Store.BarackObama - The Official Online Store for Barack Obama for President Campaign.
In terms of cons...it is kind of pricey, sometimes it feels like entering data into Volusion is time consuming and that there *should* be a better way to do it (but I don't know if this is something particular to Volusion, or to webdesign/site maintenance in general-- tedious data entry type stuff), and... that is all that is coming to mind right now.