I have a challenge I hope someone can help me with.

I have a design that I intend do using a combination screen print background and heat transfer main item.
By this I mean I will first screen print the background and then cure it.
Afterwards I will add the main art that simply cannot be printed well.
I will then have to heat press the whole image.
Has anyone done this before?
Did it work?
What do I have to look out for?
Sean Cody