I have never understood how anyone can make money with these print on demand sites. Here is information pulled from the CafePress site:
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Originally Posted by cafepress.com |  | | | | | | | | | A quick snapshot of life at CafePress:
The CafePress.com web site averages 11 million unique visits per month
Approximately 2000 new, independent shops join the CafePress.com network each day
Roughly 45,000 new, unique products are added each day
Our users have created a catalog of over 150 million unique products | |  | |  | |
From my experience, the cafepress site is saturated with sub par designs from hundreds of thousands of "virtual store owners". I couldn't imagine trying to compete with 2,000 new competitors each day. For the stores that have good designs, it is nearly impossible for buyers to sift through all of the garbage to actually find the good sites. On top of that, the collective value of each product of the "150 million unique products" is diminished due to the supply. People take one terrible design and slap it on everything from t-shirts, bumper stickers, mouse pads, etc. I don't see it being profitable for anyone except cafepress.